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THE EFFECT ON BLOOD AND URINE OF THE INGESTION OF SODIUM BICARBONATE
Author(s) -
Matthews D. L.,
O'Connor W. J.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001985
Subject(s) - excretion , chemistry , urine , bicarbonate , medicine , sodium , endocrinology , sodium bicarbonate , net acid excretion , ingestion , biochemistry , organic chemistry
O·145M NaHCO 3 given by stomach tube to conscious dogs caused a fall in plasma solids (protein), decrease in plasma Cl and increase in HCO 3 ; pH of the arterial blood increased but any increase of arterial P CO2 , was not significant; plasma K fell. The urine after 0·145M NaHCO 3 contained increased amounts of Na with only a small increase in Cl. The increased excretion of Na + was mainly accompanied by a large excretion of HCO 3 ‐ , and the urine became alkaline and contained little NH 4 + . Changes in the excretion of inorganic PO 4 , SO 4 and K were small. Comparison was made with the effects of the same doses of Na given as 0·122M NaCl+0·023M NaHCO 3 . This caused an equal fall in plasma solids but no change in plasma Cl, HCO 3 and K. The urinary excretion of Na + increased to rates approximately the same as those produced by NaHCO 3 but the main urinary anion was Cl ‐ , the excretion of which was greatly increased. There was a small excretion of HCO 3 ‐ with larger doses. It is concluded that an important agent determining increased excretion of Na is dilution of the plasma protein, which is common to both types of experiment. The changes in plasma Cl and HCO 3 appear to be the factor which determines whether the increased excretion of Na + is accompanied mainly by HCO 3 ‐ or Cl ‐ .