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EFFECT OF ISOXSUPRINE HYDROCHLORIDE ON THE SURVIVAL RATE OF DOGS SUBJECTED TO ACUTE BLOOD LOSS
Author(s) -
Sharma P. L.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001981
Subject(s) - medicine , blood pressure , saline , anesthesia , inotrope , heart rate , shock (circulatory) , perfusion , central venous pressure
In dogs anæsthetized with pentobarbitone sodium, hæmorrhagic shock was produced by rapid bleeding. The blood pressure was maintained at 35 ± 5 mm. Hg for 4 hr., and then the shed blood was returned to the animal. Animals alive at the end of a 72‐hr. observation period were considered as survivors. In the control group only one out of ten dogs survived. All the animals developed severe watery diarrhœa Isoxsuprine hydrochloride 0·3 mg./kg. administered intravenously in 10 ml./kg. of normal saline 2 hr. after the onset of oligæmic hypotension increased the survival rate from 1/10 in the control group to 7/10 in the treated group. Only two dogs developed mild diarrhœa. The incidence of ventricular arrhythmias during fluid replacement was reduced from 7/10 to 2/10. However, when this drug was administered 4 hr. after the onset of oligæmic hypotension there was no improvement in the survival rate as compared to the control group but death was significantly delayed in the treated cases. The incidence of ventricular arrhythmias was reduced from 7/10 to 4/10. All the animals developed severe watery diarrhœa. The beneficial effect of isoxsuprine may be due to improved tissue perfusion resulting from vasodilatation and an increase in the volume of circulating fluids produced by the concomitant infusion of normal saline to sustain the blood pressure above 30 mm.Hg. Another factor might be the positive inotropic action of this drug. It is suggested that isoxsuprine may prove useful in the management of oligæmic shock in man.