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THE EFFECT OF POSTERIOR PITUITARY HORMONES ON THE CALCIUM, MAGNESIUM, PHOSPHATE AND CHLORIDE METABOLISM OF SHEEP
Author(s) -
Moodie E. W.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001968
Subject(s) - calcium , posterior pituitary , oxytocin , magnesium , endocrinology , vasopressin , medicine , chemistry , phosphate , metabolism , hormone , calcium metabolism , chloride , pituitary gland , biology , biochemistry , organic chemistry
The effect of posterior pituitary hormones on the calcium, magnesium, inorganic phosphate and chloride metabolism of five female sheep was studied. Each sheep was subjected to a control observation and to intravenous injections of 450 mU per minute for 30 min. of each of the following: oxytocin (both with and without pretreatment with 5 mg. diethylstilboestrol subcutaneously), pituitary (posterior lobe) extract and vasopressin. Changes in arterial blood concentrations and in absorption from the digestive tract of calcium, magnesium, inorganic phosphate and chloride were estimated. Oxytocin markedly reduced the arterial concentrations of inorganic phosphate and probably increased the absorption of calcium. Vasopressin temporarily increased the arterial blood inorganic phosphate concentration and probably reduced calcium absorption. No effect was observed on the magnesium and chloride metabolism of the sheep as a result of any treatment. The results are discussed in relation to milk fever (parturient hypocalcæmia) in cattle.