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URINARY EXCRETION OF BETA‐HYDROXYBUTYRATE AND ACETOACETATE DURING EXPERIMENTAL KETOSIS
Author(s) -
Galvin R. Dennis,
Harris Janet A.,
Johnson Robert E.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001958
Subject(s) - ketosis , ketone bodies , endocrinology , excretion , medicine , urine , urinary system , chemistry , creatinine , metabolism , diabetes mellitus
Acetoacetate and beta‐hydroxybutyrate in blood and urine have been studied in experimental ketosis produced in healthy young men and women by: (a) exercise in the post‐absorptive state, (b) starvation and exercise, or (c) a high‐fat, low‐carbohydrate diet. With an increasing severity of ketosis, the plot of rate of excretion of acetoacetate against its concentration in the blood was a straight line, whereas the plot of the rate of excretion of beta‐hydroxybutyrate against its concentration in the blood was exponential. The two ketone bodies had a constant ratio in the plasma, but, as ketosis progressed, beta‐hydroxybutyrate became the preponderant molecule in the urine. The renal clearances of both acetoacetate and beta‐hydroxybutyrate were much lower than that for creatinine.