Premium
THE EFFECT OF CÆSIUM IONS ON NEUROMUSCULAR TRANSMISSION IN THE FROG
Author(s) -
Ginsborg B. L.,
Hamilton J. T.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001955
Subject(s) - neuromuscular transmission , ion , caesium , chemistry , amplitude , transmission (telecommunications) , neuromuscular junction , biophysics , physics , endocrinology , neuroscience , biology , inorganic chemistry , electrical engineering , optics , organic chemistry , engineering
The effect of Cs + on neuromuscutlar transmission in the frog has been investigated. In both K + ‐containing and K + ‐free solutions, the presence of Cs + allowed a gradual increase in the amplitude of the evoked end‐plate potential (e.p.p.) which was due to an increase in the output of transmitter. However, after prolonged exposure to Cs + in K + ‐free solutions, the duration of the e.p.p. was increased and its amplitude progressively reduced, eventually to zero. The effects of Cs + were reversible. The results are consistent with the idea that exposure to Cs + ions allows their entry into nerve terminals in exchange for K + ions, thereby resulting in an increased duration of the projunctional action potential.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom