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THE EFFECT OF CÆSIUM IONS ON NEUROMUSCULAR TRANSMISSION IN THE FROG
Author(s) -
Ginsborg B. L.,
Hamilton J. T.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001955
Subject(s) - neuromuscular transmission , ion , caesium , chemistry , amplitude , transmission (telecommunications) , neuromuscular junction , biophysics , physics , endocrinology , neuroscience , biology , inorganic chemistry , electrical engineering , optics , organic chemistry , engineering
The effect of Cs + on neuromuscutlar transmission in the frog has been investigated. In both K + ‐containing and K + ‐free solutions, the presence of Cs + allowed a gradual increase in the amplitude of the evoked end‐plate potential (e.p.p.) which was due to an increase in the output of transmitter. However, after prolonged exposure to Cs + in K + ‐free solutions, the duration of the e.p.p. was increased and its amplitude progressively reduced, eventually to zero. The effects of Cs + were reversible. The results are consistent with the idea that exposure to Cs + ions allows their entry into nerve terminals in exchange for K + ions, thereby resulting in an increased duration of the projunctional action potential.