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REINNERVATION OF SUBMAXILLARY GLANDS AFTER PARTIAL POSTGANGLIONIC DENERVATION
Author(s) -
Emmelin N.,
Perec C.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001940
Subject(s) - reinnervation , denervation , submaxillary gland , stimulation , submandibular gland , chorda , duct (anatomy) , endocrinology , medicine , anatomy , chemistry , biology , neuroscience , taste
Supersensitivity following section of the chorda tympani within the hilum of the submaxillary gland of the cat, producing decentralization and partial postganglionic denervation, was found not to diminish during six months provided that preganglionic regeneration was prevented. When this was allowed to occur there was a very marked reduction of the sensitivity, a pronounced increase of the choline acetyltransferase activity, a lively secretion in response to chorda stimulation: the secretory responses to eserine injected into the gland through the salivary duct, which were very small shortly after the operation, increased in spite of decreasing sensitivity. These observations are taken as evidence that collateral regeneration occurred from the remaining postganglionic neurones but only when contact with the central nervous system had been re‐established by preganglionic regeneration.