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THE EFFECTS OF VASOPRESSIN, THEOPHYLLINE AND CYCLIC 3'‐5'‐ADENOSINE MONOPHOSPHATE (CYCLIC AMP) ON SODIUM TRANSPORT ACROSS THE FROG SKIN
Author(s) -
Baba W. I.,
Smith A. J.,
Townshend Mary M.
Publication year - 1967
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1967.sp001936
Subject(s) - theophylline , vasopressin , sodium , frog skin , medicine , chemistry , adenosine , endocrinology , efflux , sodium channel , biology , biochemistry , organic chemistry
The effects of vasopressin, theophylline and cyclic AMP on sodium transport across isolated frog skin have been studied using 24 Na for the measurement of sodium fluxes. Both vasopressin and theophylline produced consistent increases in short‐circuit current, sodium influx and efflux, with a reduction in partial resistance of the skin. The same results were obtained with cyclic AMP only when it was combined with small (loses of theophylline which were by themselves ineffective. The similarity of effect of these three compounds on sodium transport mechanisms strengthens the hypothesis that the physiological activity of vasopressin may be mediated by cyclic AMP.