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INFLUENCE OF INCREASING HEART RATE ON THE ALTERATIONS OF THE CARDIAC VENTRICULAR FIBRE‐CELLS ACTION POTENTIALS INDUCED BY THIAMINE DEFICIENCY
Author(s) -
Rapuzzi G.,
Rindi G.
Publication year - 1967
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1967.sp001913
Subject(s) - thiamine , thiamine deficiency , medicine , heart rate , endocrinology , chemistry , biophysics , cardiology , biology , blood pressure
In rats, the action potentials of myocardial fibre‐cells in avitaminosis B 1 , induced by a deficient diet or by pyrithiamine administration, were measured by fluctuating microelectrodes on hearts in situ at spontaneous and at externally increased heart rate. The increasing of the heart rate enhanced the modifications of the action potentials of spontaneously beating thiamine‐deficient hearts. This suggests that the increased rate may determine a reduction in ion gradients on both sides of the cell membrane. The slowed spontaneous heart rate of thiamine‐deficient rats seems to allow full recovery of the membrane ionic distribution, even if the underlying ion processes were greatly reduced.