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AFFERENT NERVOUS DISCHARGE FROM THE CANINE LIVER
Author(s) -
Andrews W. H. H.,
Palmer J. F.
Publication year - 1967
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1967.sp001912
Subject(s) - afferent , stimulation , receptor , carnivora , sensory system , medicine , cats , chemistry , anatomy , endocrinology , neuroscience , biology
Afferent action potentials were recorded from dissected strands of divided hepatic nerves in the dog. Stimulation of sensory receptors could be produced by (a) injection of sodium cyanide into the hepatic circulation; (b) occlusion of the posterior vena cava, with resultant hepatic congestion; (c) mechanical increase of biliary pressure. Injection of acetylcholine into the hepatic circulation usually led to a profuse discharge in the hepatic nerves which, in some experiments, provoked an arterial pressor response, related temporally to the action potentials. Many hepatic nerves exhibited an abundant afferent resting discharge, but the nature of the receptors responsible was not determined.