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ARTIFICIAL PLACENTAE: COMPARATIVE RESULTS WITH TWO GAS EXCHANGERS
Author(s) -
Lawn L.,
McCance R. A.,
Thorn A. E.
Publication year - 1967
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1967.sp001898
Subject(s) - arterial blood , pulse pressure , blood flow , mean arterial pressure , amniotic fluid , medicine , hemodynamics , volume (thermodynamics) , blood pressure , anesthesia , chemistry , fetus , pregnancy , biology , heart rate , physics , quantum mechanics , genetics
A fixed volume gas exchanger has been constructed from sintered nickel plates and compared with the reservoir gas exchanger previously described. Satisfactory gas exchange was obtained through the plates, but it is difficult to define the characteristics of the apparatus quantitatively. Raising the arterial resistance reduced the ‘umbilical’ blood flow through both exchangers. With the reservoir exchanger, raising the ‘amniotic’ pressure reduced the flow of blood through the fœtus. ‘Umbilical’ venous pressure increased and ‘umbilical’ arterial pulse pressure fell and fœtal volume decreased. Lowering the ‘amniotic’ pressure decreased the ‘umbilical’ arterial flow but increased ‘umbilical’ venous flow, so that fœtal volume increased. ‘Umbilical’ venous pressure decreased and ‘umbilical’ arterial pulse pressure increased. With the fixed volume exchanger, raising the ‘amniotic’ pressure reduced the flow of blood through the external circuit. ‘Umbilical’ arterial and venous mean pressures increased and arterial pulse pressure slightly increased. Decreasing the ‘amniotic’ pressure increased the flow of blood through the external circuit ‘Umbilical arterial and venous mean pressures were reduced and there was a small increase of arterial pulse pressure.