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SOME RELATIONSHIPS BETWEEN THE LYMPHATIC SYSTEM, THE BILIARY SYSTEM AND THE BLOOD VASCULAR SYSTEMS IN THE LIVER OF THE RABBIT
Author(s) -
Lozano I. Del Rio,
Andrews W. H. H.
Publication year - 1966
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1966.sp001867
Subject(s) - lymph , albumin , lymphatic system , chemistry , bilirubin , medicine , serum albumin , endocrinology , pathology
Hepatic lymph was collected in anaesthetised rabbits. The rate of flow was variable and flows of 0·8 to 12·0 ml. per hour were recorded; in 75 per cent of the experiments it was 0·5 to 1·0 ml./kg./hr. Within a few minutes of biliary obstruction there was an increase in flow rate and a decrease of protein concentration. After biliary obstruction, bilirubin and sulphobromophthalein (BSP), when the dye had been injected intravenously, appeared in lymph, but the green pigment of bile was never present. After intravenous injection, radio‐active sodium and potassium appeared rapidly in hepatic lymph in virtually the same concentration as in plasma. Iodinated ( 131 I) albumin and T‐1824 appeared more slowly and did not come into equilibrium with plasma until a period of about 50 minutes had elapsed. BSP was present in lymph, other than in traces, only after biliary obstruction: it appeared more rapidly than did albumin, and its chromatographical pattern differed considerably from that of the bile present in the bile duct. When albumin and BSP were combined in vitro before intravenous injection, the dye reached a maximum concentration in hepatic lymph before the albumin. Iodinated albumin, when placed on the surface of the liver, passed rapidly into plasma, and thence into lymph. Colloidal, radioactive gold did not pass from the surface into lymph.