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THE EFFECT OF BENZOTHIADIAZINE DIURETICS ON THE RENAL CONCENTRATING MECHANISM OF THE SHEEP
Author(s) -
Cross R. B.,
Thornton W. M.
Publication year - 1966
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1966.sp001864
Subject(s) - reabsorption , vasopressin , chemistry , diuretic , benzothiadiazine , endocrinology , medicine , excretion , renal physiology , kidney , biochemistry , organic chemistry
The effects of an infusion of vasopressin (40 m. U. I. V.) were studied in conscious sheep. Vasopressin caused consistent increases in urinary total solute and K output and variable increases in Na and Cl excretion. Vasopressin always increased water reabsorption relative to solute reabsorption, although an antidiuresis did not occur when the initial urine concentration exceeded 1000 µ osmoles/mnl. Prior administration of therapeutic doses of diuretic or anti‐hypertensive drugs of the benzothiadiazine group modified the action of vasopressin. Water reabsorption relative to solute reabsorption was still increased, but vasopressin no longer produced increases in total solute output. The increases in K and Cl excretion were significantly smaller than those seen in the untreated animals.