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INTERACTION OF ADRENERGIC ALPHA AND BETA‐RECEPTOR BLOCKING AGENTS ON THE BLOOD PRESSURE RESPONSE TO ADRENALINE AND NORADRENALINE
Author(s) -
Sharma P. L.
Publication year - 1966
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1966.sp001861
Subject(s) - propranolol , phenoxybenzamine , medicine , epinephrine , endocrinology , norepinephrine , adrenergic receptor , blood pressure , heart rate , chemistry , pressor response , adrenergic , alpha (finance) , receptor , construct validity , nursing , dopamine , patient satisfaction
The interaction of adrenergic alpha and beta‐receptor blocking agents on the blood pressure response to adrenaline and noradrenaline was studied in anaestheitzed dogs. Dibenzyline completely blocked the pressor response to noradrenaline, and converted the pressor response to adrenaline into a depressor one. Propranolol partially restored the pressor responses to both noradrenaline and adrenaline. The increase in heart rate produced by catecholamines was completely blocked by propranolol. In another group of dogs, propranolol was administered before dibenzyline. Propranolol potentiated the pressor responses to both adrenaline and noradrenaline. The potentiation was more marked with adrenaline than noradrenaline. The increase in heart rate produced by these catecholamines was completely blocked by propranolol. Dibenzyline reduced but did not abolish the pressor responses to both adrenaline and noradrenaline. Propranolol partially antagonizes the action of dibenzyline. This antagonsim appears to be independent of the myocardial actions of adrenaline and noradrenaline.