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THE ACTION POTENTIAL OF CARDIAC VENTRICULAR FIBRE CELLS DURING THIAMINE DEFICIENCY
Author(s) -
Rindi G.,
Rapuzzi G.
Publication year - 1966
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1966.sp001860
Subject(s) - thiamine , thiamine deficiency , repolarization , bradycardia , medicine , endocrinology , chemistry , cardiology , electrophysiology , heart rate , blood pressure
The myocardial fibre cell action potentials of rats, made thiamine deficient by a synthetic diet or by antivitamin treatment (pyrithiamine or oxythiamine), have been measured in Situ by means of fluctuating microelectrodes. Although the amplitude of the action potential was unchanged, its duration was distinctly increased, owing to a lessened repolarization. Bradycardia, which was also found in thiamine deficiency, was viewed essentially as a consequence of the slowed cellular membrane recovery processes.