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THE INCORPORATION OF IRON INTO HÆMOGLOBIN IN THE DOMESTIC FOWL
Author(s) -
Ramsay W. N. M.
Publication year - 1966
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1966.sp001851
Subject(s) - fowl , labelling , iron isotopes , chemistry , ferric , in vitro , hemoglobin , biochemistry , medicine , endocrinology , radiochemistry , andrology , biology , inorganic chemistry , paleontology , physics , quantum mechanics , isotope
In the hen, subcutaneous [ 59 Fe] ferric citrate is removed rapidly from the site of injection. The erythrocytes do not become strongly labelled immediately, although plasma radioactivity is high for several hours after the injection. Maximum labelling develops after 10–11 days. After the first day, the specific activities of total erythrocyte iron and hæmin iron are virtually identical, and the maximum, once reached, is maintained for a further 2 weeks. Normal erythrocytes do not utilize labelled plasma iron in vitro , but prior bleeding causes the appearance of cells which do. It is concluded that the normal erythrocytes of the hen do not take up iron from the plasma. If hæm synthesis takes place in the circulation, it is probably confined to cells recently released from the marrow, which may contain the necessary traces of non‐hæm iron.