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THE BEHAVIOUR OF PLATELETS IN VIVO
Author(s) -
Silver M. D.,
Stehbens W. E.
Publication year - 1965
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1965.sp001788
Subject(s) - platelet , hyaline , chemistry , platelet aggregation , cellulose , thrombin , in vivo , endothelium , platelet adhesiveness , adenosine diphosphate , biophysics , biochemistry , pathology , immunology , medicine , biology , microbiology and biotechnology
Observations have been made on platelet behaviour in non‐inflamed and growing blood vessels in the rabbit ear chamber. Platelets showed little tendency to aggregate or to adhere to endothelium. Most commonly a few adhered to leucocytes which were attached to or rolled along the endothelium. Platelets adhered to leucocytes in larger numbers and aggregated to form microthrombi and emboli following mild trauma and intravascular injection of adenosine diphosphate, Pelikan ink and methyl cellulose. Following intravascular administration of thrombin and bacterial lipopolysaccharides ( S. typhosa and E. coli ) platelet aggregation was observed and later hyaline thrombi. In addition, aggregation of erythrocytes occurred with methyl cellulose.