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CHANGES IN THE COMPOSITION OF SHEEP MUSCLE DURING MALNUTRITION AND COBALT DEFICIENCY
Author(s) -
Holmes E. G.
Publication year - 1965
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1965.sp001782
Subject(s) - cobalt , intracellular , extracellular , chemistry , nitrogen , biochemistry , body water , endocrinology , medicine , composition (language) , zoology , inorganic chemistry , biology , organic chemistry , body weight , linguistics , philosophy
Specimens of muscle removed at biopsy from normal, malnourished and cobalt deficient wethers have been analyzed for total and extracellular water, total and non‐saponifiable lipid, total, TCA soluble and collagen nitrogen. The extracellular water was measured both as chloride space and thiocyanate space: the two methods gave similar values. In both malnutrition and cobalt deficiency the total muscle water, extracellular water and collagen are increased, and the total nitrogen diminished. This is still the case if the results are considered in terms of lipid‐free tissue. The non‐collagen nitrogen is diminished in the muscle of the malnourished and cobalt‐deficient groups, while the intracellular water is increased. This results in adiminution of the concentration of non‐collagen nitrogen in the intracellular water, which is most marked in the malnourished group. In general the figures for the malnourished and cobalt‐deficient group are similar, except that the cobalt‐deficient group have markedly less TCA soluble nitrogen. If total nitrogen is expressed as a percentage of lipid‐free muscle solids, it is almost the same in all three groups, in spite of the differences in its distribution.