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ALDOSTERONE AND THE METABOLISM OF MAGNESIUM AND OTHER MINERALS IN THE SHEEP
Author(s) -
Scott D.,
Dobson A.
Publication year - 1965
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1965.sp001768
Subject(s) - aldosterone , endocrinology , medicine , potassium , magnesium , sodium , intramuscular injection , chemistry , urine , metabolism , primary aldosteronism , organic chemistry
D‐aldosterone was infused into sheep at a rate similar to that at which it is secreted by the adrenal gland during acute sodium deprivation. The infusion produced a consistent fall in magnesium concentration in the plasma which could not be attributed solely to hæmodilution. This hypomagnesæmia was not exacerbated by an increased intake of potassium. Aldosterone infusion produced many of the changes in mineral levels in the plasma associated with primary aldosteronism in the human. Changes produced in the amount of magnesium appearing in the urine by intramuscular injection of aldosterone were due to the injection procedure rather than to the aldosterone. Neither intramuscular injection of aldosterone nor acute sodium depletion produced hypomagnesæmia.