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THE EFFECT OF PAPILLARY MUSCLE DAMAGE ON ATRIOVENTRICULAR VALVE FUNCTION IN THE LEFT HEART
Author(s) -
Hider C. F.,
Taylor D. E. M.,
Wade J. D.
Publication year - 1965
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1965.sp001766
Subject(s) - papillary muscle , ventricle , isometric exercise , medicine , cardiology , contraction (grammar) , mitral valve , systole , anatomy , diastole , blood pressure
The effects on competence of the mitral valve and the rate of development of isometric tension within the left ventricle have been studied by comparing dogs in which a papillary muscle was inactivated by ethanol injection with control dogs in which a similar injection was made into the lateral wall of the left ventricle. Immediately after the alcohol injection into papillary muscle three dogs out of eleven developed mitral incompetence. This does not appear consistent with the theory that papillary muscle contraction is essential for valve competence during ventricular contraction. Three months after the injection nine dogs survived in each group. Mitral valve dysfunction was present in five experimental, but in only one control dog and there was a trend to less efficient isometric contraction of the left ventricle in the experimental group. Possible reasons for these findings are discussed and a predominant rôle for the papillary muscles during the isometric rather than the ejection phase of ventricular systole supported.