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THE EFFECT OF BILE SALTS ON THE LYMPHATIC ABSORPTION BY THE UNANÆSTHETIZED RAT OF INTRADUODENALLY INFUSED LIPIDS
Author(s) -
Morgan R. G. H.
Publication year - 1964
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1964.sp001751
Subject(s) - oleic acid , absorption (acoustics) , chemistry , lymph , fatty acid , olive oil , lymphatic system , medicine , bile acid , food science , biochemistry , pathology , materials science , composite material
Emulsified and unemulsified fat was infused intraduodenally at a steady rate in unanaesthetized rats with lymph fistulhe. The output of esterified fat in the lymph reached a steady state which was considered to mirror fat absorption from the lumen. In animals which also had bile fistulae the effect of addition or removal of sodium taurocholate was measured. Unemulsified olive oil or oleic acid and mono‐olein sol was poorly absorbed in the absence of bile. Emulsified olive oil was better, but still incompletely, absorbed. In all these cases the addition of sodium taurocholate increased the absorption to that found in control animals with normal bile flow. Emulsified oleic acid was as well absorbed in bile fistula animals as in controls and the return or removal of taurocholate did not affect the output of esterified fat in the lymph. These results do not support a defect in epithelial re‐esterification of fatty acids in the absence of bile.