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THE PERMEABILITY OF THE BLOOD CAPILLARIES OF THE LEG TO THE LIPOPROTEINS IN VARIOUS HYPERLIPAEMIC STATES IN THE RABBIT
Author(s) -
Courtice F. C.,
Munoz-Marcus M.,
Garlick D. G.
Publication year - 1964
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1964.sp001750
Subject(s) - cortisone , chylomicron , cholesterol , lymph , chemistry , endocrinology , medicine , lipoprotein , vascular permeability , endothelium , lesion , alloxan , very low density lipoprotein , biochemistry , biology , pathology , diabetes mellitus
The transference of lipoproteins across the walls of blood capillaries was determined by measuring the concentration of their components in plasma and in lymph collected from the leg, both before and after injuring the paw by heat. These measurements were made in groups of normal rabbits in which the lipid levels were increased by Triton WR‐1339, cortisone, alloxan or hæmorrhage, and in cholesterol‐fed animals given either Triton or cortisone. The transference of the lipoproteins in all these different hyperlipaemic conditions was considerably increased by injury, and, both before and after injury, varied inverselv with the size of the macromolecules concerned. The results showed that one way in which Triton, cortisone and alloxan might inhibit atherosclerosis in the cholesterol‐fed rabbit was by changing the lipoprotein pattern, decreasing the amount at the lower end and greatly increasing the amount at the upper end of the spectrum in relation to size and S f values, thereby decreasing the amount of lipoprotein filtered through the vascular endothelium. The composition and stability of lipid in the lymph and, therefore, in the tissue fluid, also varied considerably in the different conditions studied and these factors were also probably important in determining whether or not lipid was deposited in an atherosclerotic lesion. The experiments support the view that small, cholesterol‐rich lipoproteins are the most likely to be deposited in the intima because they are more readily transferred across the endothelium, are rich in cholesterol, which cannot be broken down, and are probably less stable than the lipoproteins in conditions of hypertriglyceridæmia.