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CARBOHYDRATE STUDIES IN SHOCKED RATS DUE TO DESTRUCTION OF THE CENTRAL NERVOUS SYSTEM (PITHED RATS)
Author(s) -
van Gool J.,
van Willigen Hilda J.,
Hagen Hendrika
Publication year - 1964
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1964.sp001739
Subject(s) - glycogen , medicine , endocrinology , denervation , central nervous system , portal vein , shock (circulatory) , carbohydrate , hypoxia (environmental) , peripheral , chemistry , biology , oxygen , organic chemistry
After destruction of the central nervous system (pithing), rats rapidly develop hypoglycæmia with hyperlactaemia. Liver failure, due to hypoxæmia of the portal vein, exists but does not explain the rapid disappearance of blood glucose. No accumulation of free glucose in the peripheral tissues is found; but a high lactate content and an unexpected normal concentration of glycogen in the muscles explain the disappearance of glucose. Probably the normal glycogen concentration in the muscles depends on the denervation after pithing, as generally shock causes a lowering of muscle glycogen. The hyperlactæmia is explained by hypoxia in the peripheral tissues, especially the muscles, together with inability of the liver to convert lactate into glucose.