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RENAL FUNCTION IN SHEEP WITH AN EXTERIORIZED URETER
Author(s) -
Stacy B. D.,
Brook A. H.
Publication year - 1964
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1964.sp001735
Subject(s) - ureterostomy , renal function , excretion , urine , kidney , ureter , creatinine , urology , fractional excretion of sodium , transplantation , medicine , urea , sodium , endocrinology , chemistry , biochemistry , bladder cancer , organic chemistry , cancer , cystectomy
Studies of bilateral renal function have been made in four sheep with chronic unilateral ureteral fistulæ. From a comparison of PAH and creatinine excretion it was concluded that renal hæmodynamics and tubular secretory capacity for PAH were similar in the two kidneys. Also there was no gross difference between the kidneys in the rate of urine formation, the excretion of potassium and urea, and the ability to concentrate and acidify urine. When tested several months after transplantation, comparable bilateral excretion of sodium was seen in two of the experimental animals; in the other two sheep slightly more sodium was excreted by the kidney with the diverted ureter. It is concluded that cutaneous ureterostomy in the sheep does not impair renal function. This surgical preparation is therefore a valuable one for studying the function of the kidney in undisturbed sheep.