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THE REPEATABILITY OF VENTILATORY RESPONSES TO EXCESS OF CARBON DIOXIDE AND LACK OF OXYGEN
Author(s) -
Anderton J. L.,
Harris E. A.,
Slawson K. B.
Publication year - 1964
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1964.sp001703
Subject(s) - hypoxia (environmental) , repeatability , respiration , carbon dioxide , chemistry , oxygen , anesthesia , medicine , chromatography , anatomy , organic chemistry
The ventilatory responses to CO 2 without hypoxia, to hypoxia at constant P A ACO ACO2 and to CO 2 combined with hypoxia were measured in duplicate with an interval of 20 min. between the two sets of measurements. The P A ACO ACO2 threshold during the second set differed in only random fashion from that during the first set; so did the CO 2 sensitivity in the absence of hypoxia. The CO 2 sensitivity during hypoxia, however, was significantly greater during the second set of measurements. The relevance of these results to the investigation of drugs which affect respiration is discussed.