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THE VASCULAR RESPONSES OF MALE AND FEMALE RATS TO VASOPRESSIN AND OXYTOCIN FOLLOWING A SINGLE DOSE OF TESTOSTERONE PROPIONATE
Author(s) -
Honoré L. H.
Publication year - 1964
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1964.sp001700
Subject(s) - testosterone propionate , endocrinology , medicine , vasopressin , oxytocin , testosterone (patch) , hormone , blockade , castration , androgen , receptor
The vascular responses of male and female rats to the posterior lobe hormones were studied following a single dose of testosterone propionate given 24 hr. previously (1 mg.). All normal females, when treated with testosterone, became less sensitive to vasopressin; after oophorectomy testosterone had no further desensitizing effect during the period of reduced responsiveness, after which marked desensitization was shown. Most of the normal males became less sensitive to vasopressin after testosterone, but a few were more sensitive; testosterone prevented the appearance of both qualitative and quantitative changes in the vascular reactivity of orchidectomized male rats. After testosterone oxytocin became a pressor substance in the majority of both males and females. Occasionally an initial depressor phase was obtained in testosterone‐treated animals of both sexes following vasopressin and oxytocin; it was always suppressed by the administration of dihydroergotamine. These results are discussed in relation to the previously reported effects of castration, œstrogen pretreatment and sympathetic blockade.