Premium
FATTY ACID PATTERNS OF CHOLESTEROL ESTERS SYNTHESIZED BY RETICULO‐ENDOTHELIAL CELLS
Author(s) -
Day A. J.,
Fidge N. H.,
Gould-Hurst P. R. S.,
Risely D. J.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001668
Subject(s) - cholesterol , lymph , fatty acid , chemistry , coconut oil , biochemistry , metabolism , gas chromatography , chromatography , medicine , pathology
The fatty acid pattern of cholesterol esters synthesized by RE cells in rat lymph nodes was determined by gas phase chromatography. Following the uptake of cholesterol by these cells esterification with predominantly saturated fatty acids occurred. Where corn oil or coconut oil was administered together with the cholesterol the fatty acid pattern of the cholesterol esters synthesized became more unsaturated or more saturated respectively. The significance of these findings in terms of the metabolism of cholesterol by RE cells and its relevance to atherosclerosis is discussed.