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HYPOGLYCÆMIA AND SPINAL SHOCK IN RATS
Author(s) -
van Gool J.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001666
Subject(s) - blood pressure , endocrinology , medicine , hypoxia (environmental) , shock (circulatory) , hypothermia , anesthesia , oxygen , chemistry , organic chemistry
After destruction of the lower part of the spinal medulla in rats hypoglycæmia develops. Destroying other parts of the central nervous system had no such effect. Lowered arterial blood pressure was an important factor in the genesis of this hypoglycæmia. Hypotension, whatever its origin (destruction of the nervous system, hæmorrhage, extirpation of cœliac ganglion, guanethidin) lowered the blood glucose concentration, depending on the duration and degree of hypotension. In fasting rats blood pressure and blood glucose were closely related. The lowered blood pressure after cord destruction caused liver hypoxia with fatty changes and dysfunction, with high levels of SGOT and SGPT in the plasma, hyperlactæmia and hypoglycæmia. Probably liver hypoxia in reduced arterial pressure is caused by a very low oxygen concentration of the portal blood, and diminished arterial flow is less important. Hypoglycæmia is explained by insufficient gluconeogenesis, with disturbed transformation of lactate into glucose.