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THE EFFECT OF DIVERTING BILE AND PANCREATIC JUICE ON THE INHIBITION OF GASTRIC MOTILITY BY DUODENAL STIMULI IN THE UNANÆSTHETIZED RAT
Author(s) -
Morgan R. G. H.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001665
Subject(s) - duodenum , motility , medicine , pancreatic juice , chemistry , antrum , oleic acid , stomach , triglyceride , endocrinology , bile acid , pancreas , biochemistry , biology , cholesterol , genetics
The motility of the gastric antrum was recorded with a saline manometer in normal rats and in rats in which the bile and sometimes also the pancreatic juice had been diverted to the exterior. The inhibitory effects of a variety of substances infused into the duodenum were tested. There was an inhibitory response to 50 per cent glucose, 0·2N HCl or 20 per cent ethanol, which was not altered by diversion of bile or both bile and pancreatic juice. The inhibitory action of triglyceride was lost within one hour of diversion of bile, but could be restored by adding bile salts or Tween 80 to the infused fat. Neither bile salts nor Tween 80 restored the response to triglyceride in the absence of both pancreatic juice and bile. Oleic acid was an active inhibitor of antral motility in all groups, but was more effective when emulsified. Bile salts alone had no effect on gastric motility in the doses used when infused intraduodenally or intravenously. These results suggest that the material causing the inhibition of gastric motility after a fatty meal is not the triglycerides, but the free fatty acids liberated and emulsified under the combined action of bile and pancreatic juice.