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ELECTROLYTE CONSERVATION DURING THE TREATMENT OF DIABETES INSIPIDUS WITH BENZOTHIADIAZINES
Author(s) -
Kennedy G. C.,
Hill Lisa E.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001661
Subject(s) - diabetes insipidus , antidiuretic , sodium , potassium , spironolactone , endocrinology , nephrogenic diabetes insipidus , medicine , electrolyte , diuresis , chemistry , vasopressin , kidney , aldosterone , organic chemistry , electrode
No reduction in the antidiuretic effect of hydroflumethiazide in a patient with diabetes insipidus followed the administration of sufficient sodium chloride to avoid a sodium deficit. An equally large supplement of potassium chloride prevented any useful antidiuretic response, as did treatment with spironolactone. Fortunately a large potassium intake proved to be unnecessary for electrolyte balance so long as the sodium intake was high. The findings do not support the suggestion that the reduced urinary output in diabetes insipidus following benzothiadiazines is dependent upon sodium depletion.