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INTERACTION OF CO 2 AND HYPOXIC STIMULI ON VENTILATION AT HIGH ALTITUDE
Author(s) -
Tenney S. M.,
Remmers J. E.,
Mithoefer J. C.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001651
Subject(s) - acclimatization , effects of high altitude on humans , hypoxia (environmental) , altitude (triangle) , sea level , long term potentiation , hypoxic ventilatory response , anesthesia , chemistry , zoology , medicine , oxygen , biology , respiratory system , anatomy , mathematics , ecology , physical geography , geography , receptor , geometry , organic chemistry
The interaction of O 2 and CO 2 on the control of ventilation has been studied by a rebreathing technique in three healthy young male subjects, first under sea level conditions, then following 2 weeks' acclimatization to an altitude of 14,250 ft. The following results were observed: ( a ) at high altitude the family of response curves were shifted to lower values of alveolar CO 2 , and all response curves had a steeper gradient δV E /δP A ACO ACO2 than at sea level; ( b ) hypoxia potentiated the response to hypercapneic stimulus to about the same extent at sea level and at high altitude; ( c ) the ventilatory response to hypoxia was identical at sea level and at high altitude when P A ACO ACO2 was held at the normal air breathing value for the two conditions; but ( d ) potentiation of ventilatory response to hypoxia at high altitude occurred with smaller increments of CO 2 than at sea level. This was interpreted to mean that H + is an important factor in the mechanism of hypercapneic potentiation of hypoxic stimulus.