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PLASMA IRON BINDING CAPACITY AND IRON STORES IN ALTERED THYROID METABOLISM IN THE RAT
Author(s) -
Morgan E. H.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001648
Subject(s) - propylthiouracil , total iron binding capacity , endocrinology , medicine , chemistry , hemoglobin , spleen , oxygen , thyroid , serum iron , organic chemistry
Male rats were treated for 6 weeks with either thyroxine or propylthiouracil, each in two dosage levels. Then their oxygen consumption, blood hæmoglobin, plasma iron and total iron binding capacity (TIBC), and liver and spleen storage iron were measured and compared with the values from untreated control rats. The most striking changes were in TIBC which increased markedly with thyroxine and diminished with propylthiouracil treatment. There was a statistically highly significant direct correlation between TIBC‐values and oxygen consumption. It was concluded that in the rat one of the factors regulating plasma TIBC is the balance between tissue supply and demand for oxygen.