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ARTERIOLAR NECROSIS AND THE PRENECROTIC PHASE OF EXPERIMENTAL HYPERTENSION
Author(s) -
Gardner D. L.
Publication year - 1963
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1963.sp001646
Subject(s) - necrosis , polyuria , medicine , arteritis , blood pressure , nephrectomy , muscle hypertrophy , endocrinology , renal papillary necrosis , compensatory hypertrophy , cardiology , kidney , pathology , diabetes mellitus
A serial study has been made of arteriolar lesions in hypertensive rats. Following left nephrectomy, deoxycortone acetate implants lead to systemic hypertension when animals are given 1 per cent NaCl to drink. Rising blood pressure is accompanied by cardiac enlargement, compensatory renal hypertrophy, polydypsia and polyuria. These changes are detected within 3–7 days of operation. Not until 16–18 days after operation, however, is there histological evidence of the focal necrosis of visceral arterioles characteristic of rat hypertension. Early arteriolar injury is first recognized by the presence of Schiffpositive material. Only when arteritis supervenes is there evidence of an altered distribution of vascular alkaline phosphatase and 5‐nucleotidase and of a change in the medial uptake of arteriolar 35 SO 4 . The period preceding arteriolar necrosis is termed the prenecrotic phase of hypertension.