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THE VASCULAR RESPONSES OF MALE RATS TO THE POST‐PITUITARY HORMONES AFTER TREATMENT WITH DEOXYCORTICOSTERONE ACETATE (DOCA) AND CORTISONE
Author(s) -
Honoré L. H.
Publication year - 1962
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1962.sp001618
Subject(s) - cortisone , vasopressin , endocrinology , medicine , oxytocin , hormone , atropine , posterior pituitary , blood pressure , pituitary gland
The vascular responses of anæsthetized male rats to the posterior pituitary hormones were studied approximately 24 hr. after the administration of DOCA and cortisone. DOCA decreased the vascular sensitivity to the pressor effect of vasopressin in seven, but increased it in three animals. In five animals a sharp fall preceded the rise in blood pressure. After DOCA, oxytocin gave rise to three types of response—pressor, depressor and diphasic, i.e. depressor‐pressor. Cortisone increased vascular reactivity to vasopressin in ten rats but reduced it in four. In conjunction with stilbœstrol, cortisone as in the females decreased the vascular sensitivity to vasopressin. The diphasic response was obtained in most animals. Dihydroergotamine (DHE) and atropine were given to those rats showing a diphasic response to VP and either a depressor or a diphasic response to oxytocin. DHE suppressed the depressor phase in all DOCA‐treated and in most of the cortisone‐treated rats. In some cortisone‐treated animals, DHE enhanced the depressor phase and atropine given after the DHE further enhanced it. The results are discussed with regard to the autonomic nervous system and the previously reported effects of orchidectomy.