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QUANTITATIVE STUDIES ON THE SUPPRESSION OF SKELETAL LESIONS IN RATS PRODUCED BY β‐AMINOPROPIONITRILE
Author(s) -
Bell G. H.,
Khogali A.,
Sharma D. N.
Publication year - 1962
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1962.sp001603
Subject(s) - triiodothyronine , endocrinology , medicine , hormone , thyroid , thyroid hormones , chemistry
Newly weaned male albino rats were given by gavage graded doses of β‐aminopropionitrile for 4 weeks either alone or with one of the thyroid hormones viz. L‐thyroxine, D‐thyroxine, L‐triiodothyronine and D‐triiodothyronine. Some rats were given the thyroid hormones alone to see whether these hormones produced any change in the physical properties of the bones. It was found that: 1. β‐aminopropionitrile (BAPN) produced a significant fall in the breaking stress and stiffness of the bones of young growing rats. The value for strain at the elastic limit was not affected. 2. The thyroid hormones did not produce any significant change in the physical properties of the femora of normal rats. 3. Thyroxine was quite a good antagonist against BAPN. At the lower doses of the nitrile it completely prevented the lesions and, at the higher doses of BAPN, it modified greatly the toxic actions of the nitrile. L‐thyroxine and D‐thyroxine were equally effective in their action against BAPN. L‐triiodothyronine and D‐triiodothyronine were equally potent in inhibiting the lesions of 50 mg. BAPN. 4. It is suggested that the action of the thyroid hormones in antagonizing BAPN is unlikely to be due to the general metabolic effects of the hormones.