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THE EFFECT OF MAINTAINED AMMONIUM CHLORIDE ACIDOSIS ON THE RELATION BETWEEN PULMONARY VENTILATION AND ALVEOLAR OXYGEN AND CARBON DIOXIDE IN MAN
Author(s) -
Cunningham D. J. C.,
Shaw D. G.,
Lahiri S.,
Lloyd B. B.
Publication year - 1961
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1961.sp001550
Subject(s) - carbon dioxide , ingestion , ventilation (architecture) , ammonium chloride , oxygen , chemistry , respiratory acidosis , respiratory system , acidosis , respiration , ammonium , anesthesia , medicine , biochemistry , organic chemistry , anatomy , mechanical engineering , engineering
Five men ingested about 12 g. NH 4 Cl daily for about a week. Acidæmia was assessed by measuring plasma (HCO 3 ) and alveolar pCO 2 . Before, during and after the period of ingestion the subjects were given various gas mixtures to breathe, and pulmonary ventilation (V) and the alveolar gas pressures (pCO 2 , pO 2 ) were measured in the steady state. The effect of acidæmia on the parameters of the equation was examined. Only B, which is related to the “CO 2 ‐threshold”, was consistently changed, being reduced in acidæmia.