THE EFFECT OF MAINTAINED AMMONIUM CHLORIDE ACIDOSIS ON THE RELATION BETWEEN PULMONARY VENTILATION AND ALVEOLAR OXYGEN AND CARBON DIOXIDE IN MAN | Zendy

Cunningham D. J. C. | Zendy; Shaw D. G. | Zendy; Lahiri S. | Zendy; Lloyd B. B. | Zendy

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THE EFFECT OF MAINTAINED AMMONIUM CHLORIDE ACIDOSIS ON THE RELATION BETWEEN PULMONARY VENTILATION AND ALVEOLAR OXYGEN AND CARBON DIOXIDE IN MAN

Author(s) -

Cunningham D. J. C.,

Shaw D. G.,

Lahiri S.,

Lloyd B. B.

Publication year - 1961

Publication title -

quarterly journal of experimental physiology and cognate medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0033-5541

DOI - 10.1113/expphysiol.1961.sp001550

Subject(s) - carbon dioxide , ingestion , ventilation (architecture) , ammonium chloride , oxygen , chemistry , respiratory acidosis , respiratory system , acidosis , respiration , ammonium , anesthesia , medicine , biochemistry , organic chemistry , anatomy , mechanical engineering , engineering

Five men ingested about 12 g. NH 4 Cl daily for about a week. Acidæmia was assessed by measuring plasma (HCO 3 ) and alveolar pCO 2 . Before, during and after the period of ingestion the subjects were given various gas mixtures to breathe, and pulmonary ventilation (V) and the alveolar gas pressures (pCO 2 , pO 2 ) were measured in the steady state. The effect of acidæmia on the parameters of the equation was examined. Only B, which is related to the “CO 2 ‐threshold”, was consistently changed, being reduced in acidæmia.

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