Premium
THE EFFECT OF BRONCHIAL VASCULAR SYSTEM PERFUSION ON THE PULMONARY VASCULAR RESISTANCE (PVR) IN ISOLATED LUNG LOBES OF THE DOG
Author(s) -
de Burgh Daly I.,
Waaler B. A.
Publication year - 1961
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1961.sp001543
Subject(s) - vascular resistance , perfusion , lung , circulatory system , medicine , cardiology , hemodynamics
Previous experiments with isolated perfused lungs have been criticized on the grounds that the pulmonary vascular resistance (PVR) obtained has been far above the upper limit for that of a normal resting animal. In the experiments described here the PVR of lungs perfused through the pulmonary circulation alone was within normal limits. Additional perfusion of the bronchial circulation increased the PVR but not beyond the normal range. Evidence is presented which suggests that handling of the lungs before perfusion is started gives rise to a pulmonary vasoconstrictor substance derived directly or indirectly from the bronchial circulatory system but not from the pulmonary circulation. Liberation of small amounts of this vasoconstrictor substance may be responsible also for the higher PVR values observed in nonhandled lungs in which the bronchial circulation is perfused.