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PHOSPHATIDES IN THE MORPHOLOGY OF INJURED TISSUE
Author(s) -
Buckley Ian K.
Publication year - 1961
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1961.sp001540
Subject(s) - myelin , autolysis (biology) , morphology (biology) , chemistry , anatomy , biophysics , microbiology and biotechnology , biology , enzyme , biochemistry , central nervous system , genetics , neuroscience
In vitro microscopic examination of human placental tissue fragments showed development of elongate pleomorphic myelin figures within fluid filled spaces and at the tissue periphery, deformation and emigration of lipid droplets into the surrounding fluid, and formation of intravascular and peripheral translucent globular bodies which continued to form in the presence of enzyme inhibitors and were disrupted by phosphatidease “A”‐containing solutions. It is concluded that the translucent globular bodies are vesicular myelin figures caused by minimal phosphatide liberation, that lipid droplet deformation and emigration result from physico‐chemical surface changes in the lipid droplets and that the process of myelin figure formation is significant in both the morphological changes of injured tissues and tissue autolysis.