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SOME RESPONSES OF ISOLATED MUSCLE FROM THE SHEEP STOMACH
Author(s) -
Sanford J.
Publication year - 1961
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1961.sp001530
Subject(s) - abomasum , histamine , mepyramine , omasum , rumen , acetylcholine , atropine , medicine , stomach , chemistry , endocrinology , neostigmine , metiamide , reticulum , biology , biochemistry , histamine h2 receptor , antagonist , receptor , endoplasmic reticulum , fermentation
A method is described for investigating the responses to drugs of isolated strips of muscle from each compartment of the sheep stomach. Acetylcholine contracted strips of all four compartments and there were no marked regional differences in sensitivity to this drug. The action of acetylcholine was antagonized by atropine and was potentiated by neostigmine. Histamine did not contract any of the preparations but usually caused relaxation of abomasum and of rumen. Preparations of abomasum were more sensitive to histamine than preparations of rumen and contractions of abomasum in response to acetylcholine were inhibited by histamine. Mepyramine only partially antagonized the actions of histamine. Strips of rumen and abomasum were relaxed by low concentrations and contracted by high concentrations of adrenaline or nor‐adrenaline. 5‐hydroxytrytamine invariably contracted strips of reticulum rumen and abomasum but strips of omasum rapidly became insensitive to this drug.