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THE CORRELATION OF THYROID FUNCTION WITH THE RATE OF OXYGEN UPTAKE OF HUMAN LEUCOCYTES
Author(s) -
Alexander W. D.,
Bisset Sheenah K.
Publication year - 1961
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1961.sp001514
Subject(s) - euthyroid , oxygen , thyroid , medicine , endocrinology , thyroid function , chemistry , organic chemistry
The rate of oxygen uptake of leucocytes from patients with different degrees of thyroid activity was studied, and it was shown that there is a direct relationship between the oxygen uptake of leucocytes and the BMR of the patient. The leucocytes from hyperthyroid patients had an oxygen uptake of 0·185±0·037 µ M ./hr./10 7 cells. Leucocytes from euthyroid people had an oxygen uptake of 0·119±0·021 µ M ./hr./10 7 cells. The leucocytes from myxœdematous patients had an oxygen uptake of 0·083±0·016 µ M ./hr./10 7 cells. The effect of treatment on the oxygen consumption of leucocytes from three patients with myxœdema and three with hyperthyroidism was then investigated. The hyperthyroid patients were treated with 131 I and after therapy there was a decrease in the oxygen consumption of the leucocytes. In the three patients with myxœdema, the oxygen consumption of the leucocytes increased after thyroxine therapy.