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OBSERVATIONS ON THE MAST CELLS WITH SPECIAL REFERENCE TO FAT TRANSPORT
Author(s) -
Jennings M. A.,
Florey H. W.,
Robinson D. S.
Publication year - 1960
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1960.sp001475
Subject(s) - heparin , chylomicron , protamine , mast cell , endocrinology , chemistry , medicine , biology , immunology , lipoprotein , cholesterol , very low density lipoprotein
Chylomicron fat in the blood of rats in excess of the maximum physiological level produced no morphological changes in the mesenteric mast cells. The repeated intravenous injection of protamine sulphate, a heparin antagonist, during alimentary lipæmia did not result in changes in the mesenteric mast cells. As traced in autoradiographs after labelling by 35 S, the rate of mobilization of sulphated substance from the mast cells was not increased by repeated maximal alimentary lipæmia, or by repeated starvation, continued for up to 5 weeks. Thus by the methods used no connection could be shown between mast cell heparin and the clearing of chylomicron fat from the blood. This may only mean that the methods were unsuitable or insufficiently delicate for the purpose.