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FLUID INTAKE AND EXCHANGEABLE BODY SODIUM OF NORMAL AND ADRENALECTOMIZED RATS GIVEN VARIOUS CONCENTRATIONS OF SALINE TO DRINK
Author(s) -
Edmonds C. J.
Publication year - 1960
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1960.sp001454
Subject(s) - sodium , saline , dehydration , hypertonic saline , endocrinology , chemistry , medicine , tonicity , thirst , body fluid , cortisone , adrenalectomy , fluid intake , zoology , biochemistry , biology , organic chemistry
Normal rats drank increasing quantities as the salt content of their drinking water was increased. Adrenalectomized rats drank much less than normal rats when given 2 per cent or 2·3 per cent saline and some drank so little of these solutions that they died from dehydration. Cortisone restored the volume of hypertonic saline drunk to the normal level. Despite the rise in sodium chloride intake, no increase of exchangeable body sodium occurred in the normal or adrenalectomized rats when they were given hypertonic saline to drink. Serum sodium concentration increased to a small extent.