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RENAL DISEASE AND SECONDARY POTASSIUM DEPLETION IN AGEING RATS
Author(s) -
Kennedy G. C.,
Flear C. T. G.,
Parker R. A.
Publication year - 1960
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1960.sp001447
Subject(s) - potassium , medicine , endocrinology , ageing , potassium deficiency , chronic renal disease , kidney , disease , physiology , chemistry , organic chemistry
Rats, which were fed on a diet deficient in potassium for 5 weeks and then refed with normal food, replaced within 4 weeks the potassium lost from their muscles. Chronic renal lesions developed, and with their extension potassium was again lost from the muscles. Both the chronic renal damage and the potassium loss were more severe in adult than in young rats. At all ages, moreover, the renal lesions resembled those which develop spontaneously in senile rats, and which are also associated with potassium loss from the muscles. Possible reasons for this secondary potassium loss are discussed.