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THE EFFECT OF CO 2 AND 0 2 CONTENT OF THE BLOOD ON THE FREEZING POINT OF THE PLASMA
Author(s) -
Meschia Giacomo,
Barron Donald H.
Publication year - 1956
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1956.sp001174
Subject(s) - chemistry , freezing point , plasma , osmotic pressure , water content , zoology , blood plasma , freezing point depression , analytical chemistry (journal) , chromatography , thermodynamics , biochemistry , biology , physics , geotechnical engineering , quantum mechanics , engineering
1. The effect of CO 2 and 0 2 on the osmotic pressure of plasma has been estimated by measuring the freezing point depression of plasma whose blood had been equilibrated at 38° C. with gas mixtures of different composition. 2. At constant oxygenation, for each millimol of CO 2 added to one kg. of water of the blood, the osmotic pressure of plasma rises by 0·9 milliosmols per kg. of water. 3. If the CO 2 content of blood is kept constant, the reduction of one millimol of hæmoglobin (m. wt. 17,000) per kg. of water lowers the osmotic pressure of blood by about 0·3 milliosmol per kg. of water. 4. The biochemical implications of these findings are discussed.