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THE SIMILAR EFFECT OF CHYLOMICRA AND ETHANOLAMINE PHOSPHATIDE ON THE GENERATION OF THROMBIN DURING COAGULATION
Author(s) -
Robinson D. S.,
Poole J. C. F.
Publication year - 1956
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1956.sp001161
Subject(s) - ethanolamine , chemistry , lecithin , thrombin , coagulation , chromatography , chylomicron , choline , serine , inositol , biochemistry , platelet , lipoprotein , very low density lipoprotein , enzyme , cholesterol , receptor , biology , medicine , immunology
1. The addition of rat chylomicra to plasma from which the particulate fat has been removed by high‐speed centrifugation greatly increases the amount of thrombin formed in a thrombin generation test. 2. Several brain ethanolamine phosphatide preparations also markedly increase the amount of thrombin generated in similar tests. Serine phosphatide, inositol phosphatide and lecithin are inactive. 3. Acid hydrolysates of chyle contain a substance resembling ethanolamine in its ionophoretic and chromatographic behaviour. Also present are substances resembling choline and serine. 4. It is concluded that ethanolamine phosphatide is probably the phosphatide component of the chylomicron which is active in the coagulation tests.