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THE NATURE OF “WATERY VACUOLATION” OF THE LIVER CELL
Author(s) -
Aterman K.
Publication year - 1955
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1955.sp001123
Subject(s) - vacuole , cytoplasm , stain , chemistry , tonicity , ferric , isotonic , isotonic saline , liver cell , biophysics , biochemistry , biology , pathology , staining , medicine , endocrinology , inorganic chemistry
The intravenous injection of ferric carboxymethyldextran in isotonic or hypertonic saline in mice leads to the almost instantaneous formation of “watery vacuoles” in the cytoplasm of the liver cells. In specimens fixed by the method of freeze‐drying the vacuolar content gave a positive reaction with the Prussian blue stain for iron, thus showing that some of the injected material had penetrated into the liver cell. This is taken as evidence for the hæmatogenous origin of the vacuolar content. The possibility is considered that there is only one type of “watery vacuolation” despite differences in the chemical composition of the vacuolar content.