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ON THE CHANGES IN ALI‐ESTERASE AND PSEUDO‐CHOLIN‐ESTERASE ACTIVITY OF CHICKEN SCIATIC NERVE DURING WALLERIAN DEGENERATION AND THEIR CORRELATION WITH CELLULAR PROLIFERATION
Author(s) -
Cavanagh J. B.,
Webster G. R.
Publication year - 1955
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1955.sp001093
Subject(s) - wallerian degeneration , sciatic nerve , colchicine , population , degeneration (medical) , enzyme , chemistry , myelin , macrophage , medicine , endocrinology , biology , anatomy , biochemistry , pathology , central nervous system , in vitro , environmental health
1. The changes in activity of tributyrinase in chicken sciatic nerve during Wallerian degeneration have been studied and a bimodal increase has been found. The first rise in activity parallels a similar rise in pseudo‐cholinesterase activity, and on the basis of mitotic counts with the use of colchicine these enzyme changes appear to be correlated with proliferative activity of the non‐macrophage elements. The second rise in tributyrinase is considered to be a function of the invading macrophages and may be concerned with the degradation of myelin. 2. The administration of tri‐ ortho ‐cresyl phosphate initially inhibits enzyme activity in the nerve, but in no way affects subsequent changes either in the enzymes or in the nuclear population of the degenerating nerve.