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THE INFLUENCE OF CARBON DIOXIDE AND pH ON THE ELECTROCARDIOGRAM OF THE ISOLATED PERFUSED HEART
Author(s) -
Trethewie E. R.,
Hodgkinson Margaret M.
Publication year - 1955
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1955.sp001092
Subject(s) - bicarbonate , carbon dioxide , cardiology , u wave , electrolyte , medicine , electrocardiography , chemistry , anesthesia , organic chemistry , electrode
1. In the isolated cat's heart an increased CO 2 content of the perfusing fluid is associated with heightening of the T wave of the electrocardiogram when the electrolyte composition of the perfusing fluid is kept constant apart from bicarbonate change. 2. Under similar conditions a reduced CO 2 content is associated with a fall in the T wave potential. 3. The coronary flow changes in the same direction with the T wave, but equivalent changes in coronary flow alone do not cause similar changes in the T wave. 4. The significance of these findings is discussed.