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A STUDY OF CROSSED INNERVATION OF THE LUNGS IN CHRONIC PNEUMONECTOMIZED DOGS
Author(s) -
De Burgh Daly I.,
Hebb Catherine O.
Publication year - 1954
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1954.sp001074
Subject(s) - bronchoconstriction , dilator , lung , medicine , constriction , stimulation , anatomy , atropine , sympathectomy , anesthesia , vagus nerve , bronchospasm , ganglionectomy , airway , pathology , asthma , alternative medicine
1. The crossing of vagosympathetic bronchomotor fibres in the body has been investigated in dogs subjected to pneumonectomy to prevent passive effects on one lung due to activity of the other lung. The lungs were perfused at constant blood inflow to eliminate passive changes in tidal air due to alterations in lung blood volume caused by vagal effects on the heart. 2. Cervical vagosympathetic nerve stimulation on either side of the body generally gave rise to bronchoconstriction, more rarely broncho‐dilatation. Stimulation of the ipsilateral nerve caused a greater broncho‐constriction than that of the contralateral nerve. 3. In the same experiments, without the addition of atropine and in the absence of significant bronchomotor effects, pulmonary vasoconstrictor and ‐dilator fibres in the cervical and thoracic vagosym‐pathetic nerves have been shown to supply the lung on the opposite side of the body.