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CARBOHYDRATE METABOLISM IN ISCHÆMIC SHOCK
Author(s) -
Threlfall C. J.,
Stoner H. B.
Publication year - 1954
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1954.sp001043
Subject(s) - hexose , carbohydrate , glycogen , carbohydrate metabolism , fructose , medicine , shock (circulatory) , chemistry , hindlimb , endocrinology , biochemistry , enzyme
1. The “total carbohydrate” (glucose, glycogen, glucose‐l‐phosphate, fructose‐6‐phosphate and hexose diphosphate) content of normal fasting rats falls during the course of the day and the rate of this fall is increased in ischæmic shock. The effect of limb ischæmia is more marked at an environmental temperature of 30° C. than at one of 22° C. 2. Rats with a high “total carbohydrate” level at the time of injury survive longer than those with a low initial level. 3. In rats dying after hind limb ischæmia, the glucose‐6‐phosphate content of the uninjured muscle is raised whilst the concentration of hexose diphosphate is unaltered. 4. These results are discussed from the point of view that injury increases the demand on the carbohydrate stores.