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CHANGES IN OXYGEN CONSUMPTION, RADIO‐IODINE UPTAKE AND BODY TEMPERATURE FOLLOWING EXPOSURE TO COLD IN ALBINO RATS WITH HYPOTHALAMIC LESIONS
Author(s) -
Beattie J.,
Chambers R. D.
Publication year - 1953
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1953.sp001027
Subject(s) - hormone , thyroid , medicine , endocrinology , iodine , hypothalamus , chemistry , efferent , oxygen , period (music) , triiodothyronine , biology , afferent , physics , organic chemistry , acoustics
1. Male albino rats, adapted to live at 29.5°C. for a period of 7 weeks, and then exposed to a lower environmental temperature between 17° and 220° C. for 9 days, showed a rise in body temperature, oxygen consumption and radio‐iodine uptake. The thyroid glands of such rats showed changes compatible with an increase in thyrotrophic hormone output. 2. Rats adapted to live at 29.5° C. for the same period, and which had all the efferent pathways from the hypothalamus to the brain‐stem severed, showed on exposure to cold the same responses as normal rats. The rate of uptake of radio‐iodine was, however, significantly greater, indicating a higher level of thyrotrophic hormone output than normal rats exposed to cold. The histological appearances of the thyroid gland are compatible with a high thyrotrophic hormone output. The rise in body temperature was greater than that found in normal rats.